Notify people of the risk of existence-threatening respiratory depression, which include information and facts that the risk is finest when setting up OXYCONTIN or in the event the dosage is amplified, and that it could happen even at suggested dosages.
Overdose If another person has overdosed and it has major symptoms including passing out or problems breathing, provide them with naloxone if accessible, then simply call 911.
Conversion from Methadone to OXYCONTIN Regular evaluation is of individual value when converting from methadone to other opioid agonists.
The narcotic antagonists, naloxone or nalmefene, are precise antidotes for opioid overdose. Opioid antagonists shouldn't be administered during the absence of clinically sizeable respiratory or circulatory melancholy secondary to oxycodone hydrochloride tablet overdose. If necessary the appropriate dose of naloxone hydrochloride or nalmefene should be administered at the same time with attempts at respiratory resuscitation (see package insert for every drug for the details).
Precautions Right before getting oxycodone, explain to your medical professional or pharmacist Should you be allergic to it; or to other opioid discomfort relievers (such as oxymorphone); or When you've got almost every other allergies.
If a affected person has become acquiring opioid-containing drugs previous to having oxycodone hydrochloride tablets, the potency from the prior opioid relative to oxycodone must be factored into the choice of the full everyday dose (TDD) of oxycodone.
OXYCONTIN is indicated to the management of critical and persistent pain that requires an prolonged treatment method period of time with a every day opioid analgesic and for which different remedy solutions are insufficient in:
Drink Alcoholic beverages or use prescription or over-the-counter medicines that have alcohol. Utilizing items that contains alcohol throughout therapy with OXYCONTIN may cause you to definitely overdose and die.
Notify your physician all prescription drugs and supplements you employ. This opioid is frequently the drug of option for addictive use and click here can certainly bring about dependency. Some clients may produce tolerance for Oxycontin and should be slowly weaned off the drug.
To lower the chance of respiratory melancholy, proper dosing and titration of OXYCONTIN are critical [see DOSAGE AND ADMINISTRATION]. Overestimating the OXYCONTIN dosage when changing individuals from another opioid products may lead to a fatal overdose with get more info the first dose.
Oxycodone hydrochloride was genotoxic within an in vitro mouse lymphoma assay within the presence of metabolic activation. There was no proof of genotoxic potential in an in vitro bacterial reverse mutation assay (Salmonella typhimurium and Escherichia coli) or in an assay for chromosomal read more aberrations read more (in vivo mouse bone marrow micronucleus assay).
OXYCONTIN in healthier topics in pharmacokinetic scientific tests, continual-condition degrees ended up realized within 24-36 several hours. Oxycodone is extensively metabolized and eliminated mostly inside the urine as the two conjugated click here and unconjugated metabolites.
Drug interactions may possibly transform how your prescription drugs do the job or increase your hazard for serious side effects. This doc does not contain all possible drug interactions.
Acquire this medication particularly as prescribed to lower the potential risk of dependancy. Ask your physician or pharmacist For additional details.